A neutralizing agent is needed to quench the antimicrobial activity of ciprofloxacin in virtro in an experiment to determine the effect of ciprofloxacin on viability of some organisms using viable count method.
I don´t know your experimental details, of course, but couldn`t you just dilute the sample so the ciprofloxacin goes below the MIC?
QUinolones can form complexes with divalent cations, you could try to utilize ca++, mg++, Zn++ in the order. These complexes should be devoid of antibacterial activity.
If you search in the literature you should be able to retrieve a few publications on the subject.
Thank you Juan and Stefano for your contributions. I shall work on your suggestions.
Dear Stefano Biondi ,
Could you please provide references for the below;
QUinolones can form complexes with divalent cations, you could try to utilize ca++, mg++, Zn++ in the order. These complexes should be devoid of antibacterial activity.
Thank you in advance
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