Head and neck cancer is still a fatal disease particularly inoperable metastatic types. Cancer pathology regarding oncogenes & stem tumor cells is in progress, but on the other side, therapeutic protocol is still the same (surgical resection with or without chemoradiation) and the progress is only in the surgical technique or chemorad model, which cannot treat the advanced stage of cancer. One day more than 10 years ago, one senior said that the only solution to treat advanced metastatic head and neck cancer is head implantation & he meant by this virtual answer that there is no solution. Nowadays some articles start to talk virtually about this strange solution "head implantation". Even this virtual solution means loss of hope to treat cancer molecularly. I think genotherapy & stem therapy is a promising option and better than head implantation. Would you share with me your experience regarding new therapeutic options for head and neck cancer?