Freeze drying is commonly used by dairy based industry to produce dried culture of probiotics. While freeze dry processing, usually they add cryoprotective agents like skim or sucrose or MSG to maintain the stability of culture. I wonder, are there any effects of adding these cryoprotectants upon adhesive characteristic of probiotic to the human colonic intestine? Many thanks for your informations and helps. Regards- Wahyu
Most of the current studies reported a better survival of the microorganism after freeze drying. However, results may vary in different probiotic strains.
The attached article is one of the studies that investigated this topic and reported positive results.
Bests,
Shayan
http://www.ejournalofscience.org/archive/vol3no11/vol3no11_9.pdf
May be it will depend on the cryoprotectant, but we have not found any negative effect using skimmed milk. The survival during the freeze drying step improves significantly without decline the adhesion of the probiotics in the intestine.
Well, already by freeze drying most of the bacteria will stay alive. In addition, the cryoprotectectant will further protect the bacteria and number of live bacteria will be more by using cryoprotectant. To best of my knowledge the cryoprotectant don't affect the adhesion.
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