Phaeohyphomycosis is a disease caused by dematiaceous fungi Scedosporium prolificans which carries a high moratlity rate of about 80%, although the disease is confined to the animal knigdom, but given that it's mode of transmission or spread is by air, water, and wind, how far humans or immunocompromised patients are susceptible to this disease?
Anyone doing research on this disease?
Also, are there any other fungi which contain melanin in their cell wall?
Thanks in advance.
you can check my publication on phaeohyphomycosis.... we have documented a case
Thanks Dr. Iqbal...i've got it. yes, interesting case. But the patient was not immunocompromised; meaning that this fungal disease could occur in otherwise normal subjects from minor trauma (thornprick injury, wooden splinter etc.). Differential diagnosis is indeed difficult which depends on accurate histopathological examinations. However, this patient didn't exhibit any overt clinical signs and symptoms characteristic of phaeohyphomycosis.
On the other hand, in chromoblastomycosis, finding of sclerotic bodies is highly pathognomonic which however, is not a feature of phaeohyphomycosis. So, you think that normal individuals are susceptible to phaeohyphomycosis, or it might be an isolated case?
well, this was indeed a rare case report as the patient was not immunocompromised... thaz y v thought it to be worth publishing... i am not very sure about its clinical signs and symptoms because v lost the follow up of the patient afterwards but one of the reason might be that this was a subcutaneous infection at the time of presentation... thaz y the signs and symptoms were not very profound...These cases are very rare but v have found one that means there are chances of finding more...??
Dear colleague,
Phaeohyphomycosis is a very broad term applied to infections caused by dematiaceous fungi, They can involve external or internal organs and can be caused by over a hundred different fungal species ("Scedosporium" prolificans being just one of them). The only common feature is the presence of dematiaceous, septate hyphae in tissue.
Please note that the correct name for S. prolificans nowadays is Lomentospora prolificans.
This paper includes information about disseminated infections due to L. prolificans which might be of interest to your research: http://www.uca.edu.ar/uca/common/grupo11/files/mico/Feohifomicosis_010778.web.pdf
Success with your research!
Hugo
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