From the literature review, I found camptothecin, topotecan and CPT 11 as the anti-cancer agents for human topoisomerase I. But I want to know the availability of any other anticancer agents for topoisomerase I.
Can anyone help me?
Thank you.
Camptothecin
Nature. 2015 Jun 25;522(7557):492-6. doi: 10.1038/nature14513.
Cell death during crisis is mediated by mitotic telomere deprotection.
EMBO Rep. 2010 Dec;11(12):962-8. doi: 10.1038/embor.2010.157. Epub 2010 Nov 5.
DNA end resection by CtIP and exonuclease 1 prevents genomic instability.
Topotecan HCl
Nat Chem Biol. 2014 Sep;10(9):768-73. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27.
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.
PLoS Genet. 2014 Jan;10(1):e1004107. doi: 10.1371/journal.pgen.1004107. Epub 2014 Jan 16.
Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.
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