Hi, ultra small nanoparticles (USNPs) will have both advantages and disadvantages. As Subash and Sathish highlighted, the drawback of these tiny NPs is that they will be cleared from the circulation pretty quick. The advantage, however, is that they will be able to penetrate cells more readily compared to larger particles. For the same reason, they may be able to cross cell barriers (blood brain and blood testicular barriers) more efficiently. It is my view that, in order for the USNPs to be clinically useful, they will need to be tagged with (in addition to an anti-cancer drug) an appropriate ligand (eg. antibody to a cancer associated surface antigen etc) that will enable the particles to 'home in' on to the right target cell. Otherwise, their efficacy will be limited.

Best wishes

Siva

It depends on the properties of the nanoparticle.

In general, smaller nanoparticles (

In general, particle size less than 10 nm in diameter is called as ultrasmall nanoparticles and these particles are accumulated more efficiently and diffuse more deeply into the cells than larger sized nanoparticles and you can use this 5nm sized nanoparticles for intranucleus delivery too.

Hi, ultra small nanoparticles (USNPs) will have both advantages and disadvantages. As Subash and Sathish highlighted, the drawback of these tiny NPs is that they will be cleared from the circulation pretty quick. The advantage, however, is that they will be able to penetrate cells more readily compared to larger particles. For the same reason, they may be able to cross cell barriers (blood brain and blood testicular barriers) more efficiently. It is my view that, in order for the USNPs to be clinically useful, they will need to be tagged with (in addition to an anti-cancer drug) an appropriate ligand (eg. antibody to a cancer associated surface antigen etc) that will enable the particles to 'home in' on to the right target cell. Otherwise, their efficacy will be limited.

Best wishes

Siva

thanks a lot for your rational and completely acceptable respond

Shubaash Anthiya R G

Sathish Sundar

Muttuswamy Sivakumaran

The ultra small nanoparticles (USNPs) have been more effective serum- and intra-cellular diffusion in clinical applications. Also, they are significantly be able to cross blood-brain barrier that make them as great particles for fast penetration in brain cells. On the other hand, these NPs have good potency for their surface engineering such as surface modification and functionalization in order to effective delivery.

Asghar Narmani

thanks a lot for your rational and completely acceptable respond

Never.

thank you dear Qaysar M Al-Hashemi

thank you dear Qaysar M Al-Hashemi

thank you dear Qaysar M Al-Hashemi