Apoe vs. Ldlr knockout mice.

02 February 2013 1 9K Report

Why is that Apoe KO mice develop plaques even when fed on normal chow diet as compared to ldlr KO mice which only develop plaques when fed on high fat diet?

John Hill

ApoE KO mice have much higher cholesterol levels compared to LDLR KO mice and thus can develop atherosclerosis without the need for a high fat/cholesterol diet.

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