I need an advice from a pathologist or a person who is experienced/familiar with histology of intestinal tumors in mice / APCmin mouse. See attached H&E slide please. We see sometimes these huge tumors in the colon (question marks) which are different in morphology from typical tumors (adenomas) in the small intestine (red arrows). I would appreciate any advice on how to score/classify these. Any reference to literature, other resources or contacts will also be very much appreciated. We are new to this, so learning our way in. Thanks!
Hello,
I'm not a pathologist, but this looks like muca associated lymphatic tissue (MALT). If this would be the ileum then I would say this are Peyer plaques.
I hope I was able to help you.
Kind regards
Stefan
Thanks Stefan! Peyer's patches are typically much smaller. But these do look like a lymphatic tissue. I attach a zoomed-in image of the area around the most right yellow question mark on the previous image, if it will help to make a call. Thanks again.
Hello again,
on the left side it is surely lymphatic tisse and in the middle it looks like pancreatic tisse (exokrine part), because it has the morphology of an albuminous gland. I remember that in mice and rats the pancreas is embedded in the omentum majus or the mesos of the intestine and is not a organ of itself like in humans. Therefore I'm not wondering that you will find such tissue in your histology slices.
Sincerely Yours
Stefan
Stefan,
Thanks you again for such thoughtful reply. I wonder if such tissue in the colon would have something to do with intestinal tumorigenesis driven by APC mutation. Only about 10% of these mice get such large lump formations in the colon. Other 90% the colon is free of neoplasias in these mice.
Dmitry
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