The paper from Boonstra et al. 2007 (DOI: 10.1158/0008-5472.CAN-07-2064) showed that several human esophageal carcinoma cell lines were misidentifyed.
His conclusion was that TE-2, TE-3, TE-7, TE-12, and TE-13 should be regarded as one single squamous cell carcinoma cell line, however, he did not rename them.
We have been working with TE-7 and TE-13, and confirmed his results that they are genetically identical.
We have been looking for information on these cells in several Cell Banks, but they were either absent or still named as separate cell lines. Anyone knows how these cell lines have been named?
Thanks
You better go to this paper:
Boonstra JJ, et a , Mistaken Identity of Widely Used Esophageal Adenocarcinoma Cell Line TE-7. Cancer Research, 2007; 67 (17)
Well Ossama... That´s the same paper I considered in the question. Please, read my considerations after the question.
Apparently, after this papers, people have gradually discontinued the use of these cells, since we are facing a lack of information on cell banks and conflicts of information on virtual repository of genetic and protein information. For example, for COSMIC: Catalogue of Somatic Mutations in Cancer, they have information for TE-12, but not for any other identical cell names (which are obviously the same cells), although they have registered the other names on their catalogue. Therefore, it seems that, at least for COSMIC, they are not aware that the cells are identical, and treat each one as a different cell line, for the information is not shared among each cell record.
And it happens almost every cell bank we have been looking for: ATCC, eCACC, JCRB, and others.
Hi João,
I am having your same issue, trying to figure out a bit more about these cell lines. Specifically, I am looking for a cell bank to buy this cells from, or a lab that can share those with us. Where did you guys originally obtain those cells from? Based on COSMIC, I would need TE-12, but I am not sure whether other TE-s are the same identical cell line.
Any feedback is greatly appreciated.
Thanks,
Daniele
- Badges
- Science topic
- Similar topics
- Geoscience
- Asia
- India