I would like to know what the concentrations of IL-6 and TNF-a are in a.) Healthy patients, and b.) Patients with NYHA IV heart failure. Links to publications and/or clinical experience would be useful.
Dear Gemma,
I hope that this information will be helpful.
http://www.ncbi.nlm.nih.gov/pubmed/21539939
http://www.ncbi.nlm.nih.gov/pubmed/16696903
http://onlinelibrary.wiley.com.ezproxy.library.ubc.ca/store/10.1111/j.1742-7843.2006.pto_508.x/asset/j.1742-7843.2006.pto_508.x.pdf?v=1&t
Heart failure can be explained in more detail understanding the role of cold-inducible RNA-binding protein (CIRP). CIRP is upregulated in the heart and liver and released into the circulation during a systemic inflammatory response. In macrophages under hypoxic stress, CIRP translocates from the nucleus to the cytosol and is released. Recombinant CIRP stimulates the release of tumor necrosis factor-α (TNF-α) and cytokine from macrophages and induces inflammatory responses and causes tissue injury. The activity of extracellular CIRP is mediated through the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex.
Dear gemma,
Is this paper of interest to you?
Article Interleukin-6 and tumor necrosis factor-α as biochemical mar...
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