Any server to check BBB penetration ?

More Nikhil Maroli's questions See All

How can I connect two nodes using hinge connector (CONN3D2 elements) in Abaqus?

As shown in the attached picture, I am trying to connect two adjacent panels using Hinge connectors (CONN3D2 elements) with zero width and constant torsional stiffness. I wish to connect the...

06 February 2024 423 1 View

In the case of Metal-air battery (DFT approch), how can I find Entropy and Zero point energy?

Equation of Gibbs free energy G=∆E-ZPE-T∆S How finds the entropy and ZPE

08 January 2024 9,593 0 View

What method or data analysis technique can be employed to substantiate the impact of multimodal composing on enhancing the writing skills of students?

How can we demonstrate the efficacy of multimodal composing in enhancing writing skills, particularly in the context of academic writing, given the prevalent skepticism surrounding its...

07 December 2023 9,409 1 View

Can anyone tell me the difference between quantile regression and quantile on quantile regression?

when can it be used in corporate finance research?

27 November 2023 2,906 1 View

Quinolinic acid standard curve show reverse linearity when mixed with Blank serum samples?

When i use quinolinic acid in inreasing concentrations along with blank serum, the standard curve is surpisingly negatively linear! Expected linearity is reverse for this. However other standards...

18 October 2023 5,659 0 View

1 mg/ ml stock solution of kynurenic acid turn turbid when methanol is added?

When i make a stock solution of d5- kynurenic aicid (1 mg/ml), the solution is turbid and not clear. Inspite of sonication in water bath with mild heating, the suspension is not clear. Can i...

18 October 2023 9,790 0 View

Hii, Anybody has cif file for Na4VMn(PO4)3 material?

CIF file for rietveld refinement of Na4VMn(PO4)3 XRD data, using GSAS software if you have it, please provide me. Thank you in advance.

08 October 2023 7,038 3 View

How to update parameters of Bayesian neural network?

I am trying to update parameters of Bayesian neural network using HMC algorithm. However I am getting the error shown below: ValueError: Encountered `None` gradient. fn_arg_list: [] grads: [None]

19 July 2023 5,686 1 View

What is the incident radiation used in XPS and why? How does the detector used in the XPS differ from those during SEM, EDX or XRD data collection?

23 May 2023 3,642 3 View

Do conductors have band gap? Then how do you describe the band gap in conducting polymers?

Do conductors have band gap? Then how will someone describe the band gap in conducting polymers?

23 May 2023 6,402 0 View

Why do we equate male and female arousal?

Women, on the other hand, can become physically aroused (increased blood flow in the reproductive organs) without becoming psychologically aroused even in the slightest. (Robert Weiss)

05 August 2024 9,537 2 View

How can i do multivariate Time Series forecast using MLP, ANFIS and LSTM?

I need the python code to forecast what crop production will be in the next decade considering climate and crop production variables as seen in the attached.csv file.

05 August 2024 2,977 3 View

The Curse of Evolution and Complexity?

Brain and body mass together are positively correlated with lifespan (Hofman 1993). The duration of neural development is one of the best predictors of brain size, and conception is the best...

05 August 2024 6,247 3 View

ANY free software for reconstructing neurons in the microscopic image?

Hi everyone, I am working on brain slices for visualizing a protein in the soma and dendrites, using a fluorescence tag. However, I need a tool (not paid) for reconstruction of the whole neuron,...

04 August 2024 4,725 2 View

How to Add Missing Water Molecules in Protein-Membrane Simulations?

I have protein-membrane simulations (PDB, PSF, DCD) and have noticed that water molecules near the protein are not visible in the simulations. How can I fix this issue? Is there a way to place the...

04 August 2024 1,200 2 View

In what part of the brain´s rabbit bdnf is located and include references please?

I´ve been unable to find specific information about this neurotrophin in the CNS of rabbits exclusively. There is extensive info in mice, fish and rats, but in brain´s rabbit is hard to find....

04 August 2024 762 1 View

Do You Know Untreated TMJ Affects Your Brain And Entire Body?

04 August 2024 6,282 1 View

PBMC infection with virus?

In my study, I intend to infect PBMCs with SARS-CoV-2. After that, I will analyze NK cells by flow cytometry to see if their phenotype changes or if they show degranulation. After the infection, I...

01 August 2024 4,403 4 View

What is the best protocol for freezing the rat brain in preparation for protein detection by Elisa ?

What is the best way to freeze the rat brain - liquid nitrogen, Dry ice , isopentane - after isolation for later protein investigation by Elisa?

01 August 2024 1,722 1 View

How to Post-fix Mice pup's brains?

I need to Postfix mice brains. I slice the brains using microtome at 40 microns. These are Postnatal days 7, 11, 14, and 21. I am using half the brain for other analysis, so I need to fresh freeze...

31 July 2024 1,123 4 View

Hussein Kadhem A-Hakeim

You can use solubility and tendency to dissociate from albumin i.e., Kdissof albumin-substance complex

Anu Manhas

sure, check out the link

http://www.cbligand.org/BBB/

Cathie King

I am a Medical Sociologist this is not my area.

You asked for tool or server? that's why I replied with that link

Nikhil Maroli

Hi Anu,

I am aware of the server you mentioned. sorry i should have put that in the question.

Carlos A. Villalba-Galea

the http://www.cbligand.org/BBB/ tool is great. However, it predicts that ACh is BBB+. Does anyone know why?

Keong Zheng Ng

I notice that we could only input 1 drug at a time.

Is there any way to input multiple drug into cbligand?

Check this out. It is a little old, but it works OK. https://www.cbligand.org/BBB/

it has some problems with molecules like acetylcholine...