Hi Harshana Thanki for bulk purification of polyclonal antibodies, it is typically recommended to use, on a first approach, immunoglobulin-specific purification methods such as Protein A, Protein G, or Protein A/G.

Depending on your intended application, you may require a higher level of specificity. In this case, you may consider performing antigen-specific purification (by immobilizing your antigen and use it to capture antigen-specific antibodies), taking into account that you will gain in specificity and purity but heavily reduce your yield.

You can find more information on polyclonal purification processes in this article: https://www.proteogenix.science/scientific-corner/antibody-production/polyclonal-antibody-production-processes/

Hope it helps!

Ana Reis Thank you so much. Sure I will take into consideration