Is the most significant breakthrough so far "Published in Nature Aging, the new research reveals that the trick to anti-ageing lies within the white blood cells known as T cells. The researchers behind the study discovered that they can reprogram these cells to turn them into ageing-cell-killing machines known as CAR (chimeric antigen receptor) T cells.
24 ene 2024 " ( https://www.sciencefocus.com/news/slow-ageing-t-cells ).
Why eating less slows ageing
"A component of bile called lithocholic acid, which is made by gut bacteria and helps to digest fat, can extend the lifespan of some animals. Researchers found, in mice, that levels of the acid rise during calorie restriction and that it activates a protein called AMPK — which scientists have already linked to the health benefits of eating less. When the team fed lithocholic acid to nematodes (Caenorhabditis elegans) and fruit flies (Drosophila melanogaster), the animals lived significantly longer than those that had not been given it. There is no evidence yet that taking lithocholic acid would have the same effect in humans — and at high doses, it could be toxic..."
https://www.nature.com/articles/d41586-024-04220-5
https://www.nature.com/articles/d41586-024-04062-1
https://www.nature.com/articles/s41586-024-08329-5
https://www.nature.com/articles/s41586-024-08348-2
RNA molecule rejuvenates ageing mice
"Injecting old mice with an RNA molecule called miR-302b seems to reverse some signs of ageing — helping them to live longer, regrow hair and maintain their physical and mental abilities. The treatment works by targeting one of the hallmarks of the ageing process: a stage called cellular senescence, in which cells lose their ability to replicate. Researchers hope the findings could one day lead to the development of anti-ageing drugs, but more work is needed to determine whether they translate to people..."
https://www.nature.com/articles/d41586-025-00032-3
The trouble with biological age
"In the world of gerontology — the study of ageing — money is pouring into the development of tests that measure our ‘biological age’. Many such tests focus on biomarkers such as chemical marks on DNA, known as methylation. Biomarkers could prove useful as part of efforts to develop therapies that could stall the negative effects of ageing. But often, results that use them are presented without mention of the uncertainties that plague the field. Even among gerontologists, there’s little consensus as to what ‘biological age’ actually means..."
https://www.nature.com/articles/d41586-025-00566-6
An epigenetic atlas of ageing
A huge analysis of epigenetic changes throughout the entire adult lifespan provides the most comprehensive picture to date of how ageing modifies our genes. The study reveals that some human tissues, such as the retina and stomach, accumulate more ageing-related DNA changes than do others, such as the cervix and skin, and found universal epigenetic markers of ageing across different organs. This ‘atlas’ might help researchers to study the link between DNA methylation and ageing and could aid the identification of molecular targets for anti-ageing treatments...
https://www.researchsquare.com/article/rs-7184037/v1
https://www.nature.com/articles/d41586-025-02735-z
Why the magic mushroom anti-ageing claims are overblown
How can we live longer? The eternal question, and one that scientists have long been trying to answer...
"We know that diet, exercise, and genes play a big role in the ageing process and how long each of us might be alive for. We also know that certain drugs or medicines have the potential to increase our lifespan. Though there’s still a lot we don’t know about what makes one person live to 102 and another only make it to 72.
But one new study seems to suggest that psilocybin, found in so-called “magic mushrooms”, could have potential as a longevity drug. In a new study, researchers found that psilocin – the compound your body makes after ingesting psilocybin – helped human cells live longer in the lab and that psilocybin boosted survival rates in older mice.
The study has led to numerous headlines claiming that magic mushrooms could be the secret to living longer. But as someone who’s been studying psychedelic compounds like psilocybin, for the past 20 years – with a specific focus on human and rodent psychedelic dosing – I think the claims have been massively overhyped and that applying the findings to humans is deeply problematic..."
https://pubmed.ncbi.nlm.nih.gov/40628762/
https://theconversation.com/why-the-magic-mushroom-anti-ageing-claims-are-overblown-263928?
The researchers will study their newly discovered macrophages more closely to better understand their role in inflammation and ageing..
Newfound cell linked to ‘inflammageing’
A newly discovered type of immune cell found in fat tissue seems to contribute to ‘inflammageing’ — the chronic inflammation that develops with ageing — in mice. Researchers found that the new type of cell emerges in the deep fat around internal organs as mice age and produces high levels of inflammatory molecules. Other immune cells in the fatty tissue appear to keep these inflammation-boosters at bay, but their numbers dwindle later in life in females...
https://www.nature.com/articles/s43587-025-00952-9
https://www.nature.com/articles/d41586-025-02788-0
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