DMSO is usually used as a solvent or vehicle for essential oils. However, a separate top layer of oil is formed. The same goes for distilled water.
In the case of Tween-80, foam is produced and thus the solution is not clear.
Hi
In many cases must be solution from DMSO\Tween-80 in different ratio ex(9\1)
and you can use Ultrasonic as assistant method to dissolve
when you finish mix pass the mixer to US
Thank you ve.ry much for sharing this valuable information @ Hassn Aldali
I am having the same issues with my plant extracts, I understand the problem may be with the extraction method in the first place; most often the particles seem are not part of the extracts but rather shafts from when the plants were pulverized thus they will never dissolve in any solven.
The trick is to soak the extract in the aiding solvent (DMSO/Tween 80/ Methanol) for a few hours, sonicate then centrifuge (make sure you do a multiple of the concentration U need; if it’s 5mg/mL stock, do 10mg/2mL e.t.c as this will let U have at least 1mL of the stock in solutio)..
Whatever settled below is the insoluble shafts n all.
They will never dissolve as they were never extracted in d solvent in the first instance.
U can then work back the real weight of the plant material in your solution..( That’s where methanol is preferred)! {Or you remove the weight of shaft from the total weight of plant extract}…
All of this trouble is because the plant materials were not properly extracted in the first instance, so next time take care to only extract the real powder by sieving out particulates n shafts n leaving only the soluble part in your solvent of extraction.
The whole thing is like re extraction actually :D
All the best!
Adeola Folasade Odewusi-Ehigie
In this case, particulate contamination was not an issue at all. Since oil is immiscible with many liquids and usually forms a separate layer on top, we were searching for a solvent to form a homogeneous mixture.
DMSO as a solvent and sonication were helpful.
Thank you for sharing this valuable information.
Regards.
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