there are four different mechanisms for liposome uptake-adsorption, fusion, endocytosis and lipid exchange. But why do we only study endocytosis mechanism while exploring cell uptake mechanisms of liposomes?
From your question, I could not distinguish whether it is a problem about membranes in the physicochemical system in vitro or a biological problem related to the cell membrane.
In either case, endocytosis is involved in traffic and exchange, including the process of selection, of the contents confined inside membrane vesicles. Thus, endocytosis uptake is important.
Also fusion is involved in traffic and exchange. But, in the case of fusion, little for the selection process.
Dear Komalla,
I think, It could not distinguish with a problem about cell membranes in the physicochemical system in vitro but when we are going for the in vivo then a no. of things are changed due to biological problem related to the cell membrane.
In the case of endocytosis is involved in traffic and exchange, including the process of selection, of the contents confined inside membrane vesicles. So, I think endocytosis uptake is very essential for in vivo system but in vitro mechanism is different. Also fusion is involved in traffic and exchange.
Thank you for the response. But my question is about "in most of the papers I read, for studying the cell uptake mechanism of liposomes in vitro, researchers chosen and studied the endocytotic uptake of liposomes only. They didn't consider other uptake mechanisms for in vitro studies.
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