Article Eucommia ulmoides extracts prevent the formation of advanced...
This is a very important aspect of disease prevention which needs to be pursued rigorously.AGEs, ALEs and AOPPs are involved in almost all chronic inflammatory diseases. Preventing their formation may be a major step in reducing the morbidity of various chronic inflammatory diseases.
Most of these can be used as supplements to standard medication (eg. Resveratrol, L-Carnosine, Alpha Lipoic Acid, Pyridoxamine and Benfotiamine).
Please share your views and research findings (especially the dosages).
Best regards
Very interesting data. When do you expect this to be clinically applicable
In India, 2 brands Ageless and Aisa are already available. Shortly it will be moved to nutraceutical category. The results are pretty good. However, the medical fraternity is proceeding cautiously for the very safe ingredients, in the absence of hype from MNCs.
I find alpha lipoic acid a well tolerated antioxidant that acts in lipids and water.
However, if we do not want to produce harmful glycation products, we should look at the sugars involved. Galactose, in milk, is an avid glycator. I suggest eating cheese and butter and avoiding milk. Fructose, in high fructose corn syrup, agave, cane and beet sugar, honey, fruit and fruit juice, is a less avid glycator than galactose, but more avid than glucose. So eat starch rather than sugar, eat vegetables rather than fruit, eat avocado, lemon and lime rather than sweet fruit. Eat cooked green bananas as a vegetable, rather than eating sweet yellow bananas.
Bioflavonoids like resveratrol are well tolerated by the majority, but poorly tolerated by the minority who have poor sulphate conjugation of such phenols. They have poor toleration of red wine. So resveratrol should be avoided in those prone to depression, gut problems, arthritis, auto-immune diseases, chronic fatigue, migraine, multiple sclerosis, motor neurone disease, Parkinson's, and hormone related cancer.
The extra amount of glucose results in attachment with hemoglobin, proteins, fructosamine and other body parts. Though use mostly as diagnostics of diabetic complication, i feel Prabhakar Shetty has rightly pointed out that most metabolic disorders are associated with glycation.
Some of the references on ADVANCE GLYCATION END PRODUCTS are as elow:
Article An overview of in vitro and in vivo glycation of albumin: a ...
Article Relationship between soluble receptor for advanced glycation...
Article The Relationship Between Levels of Advanced Glycation End-Pr...
Hope it further elaborates your study.
Regards
true, we have a three pronged attack of AGE breaker, preventing the progression of developing AGE's/ALE's & AOPP.
this could be an ideal combination for chronic inflammatory conditions. This would take care of FAO also.
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