Hello,
Do we have inhibitors specific for the ADAM and/or ADAMTS metalloproteinase family that do not inhibit MMPs?
I found ADAM 10 "specific" inhibitors but nothing on their effect on MMPs.
Thank you
Philippe
ADAM (A Disintegrin and Metalloproteinase) and ADAMTS (A Disintegrin-like and Metalloproteinase with Thrombospondin motifs) are families of zinc-dependent metalloproteinases involved in various physiological and pathological processes, including cell adhesion, migration, proteolysis, and tissue remodeling. Specific inhibitors for ADAM and ADAMTS can be valuable tools for studying their functions and potential therapeutic interventions. Here are some examples of inhibitors for these proteinases:
ADAM Inhibitors:
TAPI-1 (TNF-α Protease Inhibitor-1): TAPI-1 is a broad-spectrum inhibitor that inhibits ADAM family members, including ADAM17 (also known as TACE - Tumor Necrosis Factor-α Converting Enzyme). It interferes with the proteolytic processing and shedding of cell surface proteins.
GI254023X: This is a selective inhibitor of ADAM10, another member of the ADAM family. It has been used in studies to investigate the role of ADAM10 in various cellular processes.
ADAMTS Inhibitors:
TIMP-3 (Tissue Inhibitor of Metalloproteinases-3): TIMP-3 is a natural inhibitor of ADAMTS proteases. It inhibits the activity of several ADAMTS family members by forming complexes with them, thereby regulating extracellular matrix remodeling.
GW280264X: This is a synthetic inhibitor that targets ADAMTS-5, a metalloproteinase associated with cartilage degradation in conditions such as osteoarthritis. It has been studied for its potential use in treating joint diseases.
It's important to note that the field of metalloproteinase inhibitors is continually evolving, and new inhibitors may be developed over time. Additionally, the specificity and efficacy of inhibitors can vary, so researchers should carefully select inhibitors based on their experimental goals and the specific ADAM or ADAMTS family member they are targeting.
Always check the latest literature and consult databases for the most up-to-date information on inhibitors and their applications in research and potential therapeutic strategies.
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