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Questions related from Philippe Mellet
We made a prodrug that should not be toxic unless the N-term protection CBZ is removed in the cytoplasm. Do you know a reference about that ? Thank you Philippe
02 June 2025 2,672 3 View
Hello, I was not able to find a natural inhibitor for Fibroblast Activation Protein (FAP) in the banks or in the literature. Even among broad spectrum inhibitors Is there any identified? Thank...
27 November 2023 663 2 View
I need to detect specifically urokinase activity in cell culture media. Also I would like to design a specific substrate bearing a new type of probe. Thanks Philippe
23 November 2017 1,957 1 View
Hello, Do we have inhibitors specific for the ADAM and/or ADAMTS metalloproteinase family that do not inhibit MMPs? I found ADAM 10 "specific" inhibitors but nothing on their effect on...
01 January 1970 1,581 2 View
Has anyone ever encountered a peptide that binds the wrong way in the protease binding pocket (meaning from c-term to n-term instead of the reverse) and that is still hydrolyzed? Just curious...
01 January 1970 5,063 3 View
