Hello,
During skeletal muscle contraction and during the actin–myosin ATPase cycle there is release of Pi and ADP. Can anyone tell me and ideally suggest a reading list of where they actually go?
Thank you
After release from the binding site during the actin–myosin ATPase cycle, both inorganic phosphate (Pi) and adenosine diphosphate (ADP) remain associated with the myosin head for a brief period. This occurs just after the power stroke, when myosin is bound to actin. Subsequently, Pi and ADP are released from the myosin head as a new molecule of ATP binds to the myosin, initiating the next cycle. This binding and release process is crucial for the cyclic interaction between actin and myosin during muscle contraction.
Habiba Sundus, All clear. However, I am particularly interested in the last part of the answer. Specifically, once the Pi and ADP are released from the myosin head as new molecules, do they remain there or are released somewhere, or dissociated ( if they are dissociated, how does this occur), or are they used up for something else?
Hello, I leave you some references that you can consult, perhaps they will give you the answer you are looking for:
- Cid, F. M. (2018). Principios de neuroeducación física. Bubok.
- Rizzo, D. C. (2009). Fundamentals of Anatomy and Physiology (Book Only). Cengage Learning.
- Scott, W., Stevens, J., & Binder–Macleod, S. A. (2001). Human skeletal muscle fiber type classifications. Physical therapy, 81(11), 1810-1816. (Find the full article on Researchgate).
https://rac.es/ficheros/doc/01008.pdf (copy and paste link in seach bar, is a spanish paper)
I have the books that I mentioned to you in Spanish, if you are interested, I can send them to you.
In general, my understanding is, that once the "power hit" of the myosin head is completed, the remaining ADP and P are separated from the myosin head.
I attach images of some books.
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