During the past decade since the onset of A(H1N1)pdm09 pandemic the antigenic profile of virus practically did not chage. Actual strains react in HI-test within 1-4-fold of homologuos titre with antiserum to the earliest propotype - A/California/07/09. There is also very little proportion of oseltamivir resistant strains comparing to pre-pandemic A(H1N1).
What is in your opinion the reason of such stability?
Actually, you have addressed a very interesting and critical issue. Although, both 2009 and 1918 H1N1 influenza virus share a common origin for the HA gene, however, the antigenic evolution of pdm09 HA gene is quite stable or rather forming one evolutionary pathway. While, based on my recent study, I have detected pdm09 antigenic variants through circulation in pig populations. Therefore, I think that changes in the antigenicity of pdm09 HA gene are speculated in human population within few years.
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