A bacterial protein can be antigenic or virulent. What is the possible way to know either the bacterial protein is virulent or not?

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Matthew James Conroy Popular answer

In order to determine if a protein is involved in virulence, see if knock-outs are still capable of infection to the same degree as wildtype

Matthew James Conroy

Manchala Nageswar Reddy

Purify the fraction of protein and immunize into suckling mice. (invivo studies)

all the best