2q duplication mechanism in two siblings?

19 February 2019 0 6K Report

There are two siblings, who have partial 2q duplication according to micro-array analysis. Their father has balanced t(2;4) and his micro-array analysis found normal. The breakpoint of father's translocation (on chromosome 2) is same as his children's duplication starting point. With which mechanism can I explain this issue? Does paternal translocation predispose the rearrangement? How?

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