Diagnostic Methods

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Questions related to Diagnostic Methods

Differences between sensitivity, specificity, accuracy for any test or method?

Usually, We read this terms ;sensitivity, specificity, accuracy in literature to describing a diagnostic methods , I am confusing to imagine a meaning of this three terms. I need an example, how...

01 January 2016 5,235 1 View

How effective is sap analysis for nutrient constraint diagnosis and fertilizer recommendation ?

A variety of plant parts-based ( Leaf analysis, Flower analysis, Fruit analysis, Sap analysis etc. ) nutrient constraint diagnostic methods are practiced in identifying the type of nutrient...

28 December 2015 9,270 36 View

Does anyone know the established diagnostic method for the detection of SNP for the the low dose (75mg) Aspirin resistant?

We know that the low dose of aspirin is used as an anti-platelet medicine, which means it reduces the risk of clots forming in patient's blood and are being used world wide because of low cost and...

19 December 2015 2,130 4 View

Any advice on insulin extraction from a Dried Blood Spot?

I am having problems getting any detected insulin from dried blood spots after extraction with PBS+Tween.I am using a common biochemical analyzer (electroluminescence) instead of ELISA (which...

15 December 2015 3,252 3 View

Any advice on insulin extraction from a Dried Blood Spot?

I am having problems getting any detected insulin from dried blood spots after extraction with PBS+Tween.I am using a common biochemical analyzer (electroluminescence) instead of ELISA (which...

12 December 2015 5,727 3 View

Does anyone in my network have experience in measuring Brain Derived Neurotrophic Factor (BDNF) in Salivary?

Is it reliable? And how should the storage of samples be carried out?

12 December 2015 827 4 View

What is the best approach to design a diagnostic testing study when there is no gold standard?

I am involved in designing a diagnostic test accuracy study in which the PI wants to compare weight bearing x-ray with gravity stress x-ray (two types of radiography) in diagnosing whether a weber...

12 December 2015 8,414 2 View

Does anyone know the established diagnostic method for the detection of SNP for the the low dose (75mg) Aspirin resistant?

We know that the low dose of aspirin is used as an anti-platelet medicine, which means it reduces the risk of clots forming in patient's blood and are being used world wide because of low cost and...

12 December 2015 4,512 4 View

How effective is sap analysis for nutrient constraint diagnosis and fertilizer recommendation ?

A variety of plant parts-based ( Leaf analysis, Flower analysis, Fruit analysis, Sap analysis etc. ) nutrient constraint diagnostic methods are practiced in identifying the type of nutrient...

12 December 2015 1,951 36 View

Any suggestions on a mutation analysis of MKKS gene?

We have diagnosed a girl with McKusick-Kaufman syndrome (MKS) based on clinical presentation with hydrometrocolpos, polydactyly, and congenital heart disease. We want to confirm the diagnosis at...

14 November 2015 8,519 4 View

Any suggestions on a mutation analysis of MKKS gene?

We have diagnosed a girl with McKusick-Kaufman syndrome (MKS) based on clinical presentation with hydrometrocolpos, polydactyly, and congenital heart disease. We want to confirm the diagnosis at...

11 November 2015 7,790 4 View

I'm intending to analyze metals in urine. What are the procedures for posterior analysis of the sample in ICPMS?

I want to quantify Fe, Cu, Ni, Sn and Cd from urine. What are the procedures for posterior analysis of the sample in ICPMS? Should I acidify the urine?

28 October 2015 9,794 3 View

What percent of your PCI patients have been pretreated with an oral P2Y12 inhibitor prior to their diagnostic angiogram +/- PCI?

Do you follow current guideline recommendations on pretreatment?

10 October 2015 2,550 2 View

I'm intending to analyze metals in urine. What are the procedures for posterior analysis of the sample in ICPMS?

I want to quantify Fe, Cu, Ni, Sn and Cd from urine. What are the procedures for posterior analysis of the sample in ICPMS? Should I acidify the urine?

10 October 2015 8,574 3 View

Is there an online tool to draw lines on Fagan's nomorgam and calculate post-test probability?

I am writing an article about Fagan's nomogram. I want to add an example for calculation of post-test probability using Fagan's nomogram. I need an online tool for accurate presentation of...

09 September 2015 9,390 3 View

How common is a perfect diagnostic measure (100% Sens, Spec, PPV, NPV, AUC)?

I've performed analyses on a series of variables, 3 of which yielded 100% sensitivity, 100% specificity, 100% positive predictive value, 100% negative predictive value, AUC of 1.0 (1.0,1.0). I did...

28 August 2015 7,493 6 View

How common is a perfect diagnostic measure (100% Sens, Spec, PPV, NPV, AUC)?

I've performed analyses on a series of variables, 3 of which yielded 100% sensitivity, 100% specificity, 100% positive predictive value, 100% negative predictive value, AUC of 1.0 (1.0,1.0). I did...

08 August 2015 6,098 7 View

Are there any references on ideal dimensions and measurements of lateral flow immunoassay components?

i am searching for a source that contains dimensions, measurements and technical aspects associated with lateral flow immunoassay components (sample pad, conjugate pad, nitrocellulose membrane,...

06 June 2015 5,685 1 View

In order to identify individuals who have poor posture, which diagnostic method is available?

To measure the effectiveness of the use of a corset, first we want to identify individuals with poor posture. We need a reliable diagnostic method to do so, the risk groups are often Kyphosis...

06 June 2015 814 12 View

In order to identify individuals who have poor posture, which diagnostic method is available?

To measure the effectiveness of the use of a corset, first we want to identify individuals with poor posture. We need a reliable diagnostic method to do so, the risk groups are often Kyphosis...

01 June 2015 2,010 11 View

What would be the minimum sensitivity required for validating a diagnostic assay?

When we are developing a diagnostic assay, we have to consider about sensitivity and specificity. Is there any standard value for minimum sensitivity of a validated assay?

05 May 2015 7,776 4 View

Is it possible to diagnose lymphosarcoma from partly autolysed poorly fixed organ samples?

The lymph nodes were collected at postmortem but did not fix properly making histopathological diagnosis impossible. Are there any other diagnostic method that can be used on the fixed sample to...

22 April 2015 10,055 4 View

Is it possible to diagnose lymphosarcoma from partly autolysed poorly fixed organ samples?

The lymph nodes were collected at postmortem but did not fix properly making histopathological diagnosis impossible. Are there any other diagnostic method that can be used on the fixed sample to...

04 April 2015 4,230 5 View

How can I isolate cells from bile fluid?

I want to isolate cells from bile to extract DNA and evaluate some biomarkers. I did not any clear method in the literature to do it. Did anybody can give me some idea?

04 April 2015 836 2 View

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