Amit Kumar Acharzo

4 Questions 5 Answers 0 Followers

Questions related from Amit Kumar Acharzo

Why solute back from a solution when increasing pH?

I dissolved a poorly soluble drug molecule into a solution of 0.1N HCl and β-cyclodextrin, but when I increased the pH by adding NaOH, the solute returned from the solution and turned the solution...

18 January 2022 438 3 View

Why does my formulated tablet crumbled into large fragments instead of tiny granules or particles during in vitro dissolution testing?

I am developing a tablet of bcs class 2 molecule. I used here Magnesium stearate, microcrystalline cellulose, povidone K-30, sodium starch glycolate. Coating: Hypromellose, iron oxide black, PEG...

01 May 2021 1,847 6 View

What is the example of hydrogel forming agent having molecular weight range between 100,000 and 8,000,000?

I am trying to develop of a Sustain release drug (BCS class I). so that, I want to use a hydrogel forming agent which molecular weight out of range between 100,000 and 8,000,000. I am also wanting...

27 March 2021 176 3 View

What are the impacts of pKa1and pKa2 in drug absorption ?

Pregabalin is a crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. what insight can i get from this aforementioned information during drug design. What is the difference between pKa1and pKa2.

29 December 2020 7,372 3 View