Pregabalin is a crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. what insight can i get from this aforementioned information during drug design. What is the difference between pKa1and pKa2.
pKa1 is the pKa of the carboxylic acid group and pKa2 is the pKa of the amino group. With this information, you can calculate the average charge on the drug as a function of pH. The charge will influence the rate of absorption, as well as the mechanism of absorption.
Adam B Shapiro sir would you please provide me any article on it
https://www.pharmatutor.org/pharmacology/general-pharmacology/physical-properties-drugs.html#:~:text=The%20weak%20base%20is%20absorbed,due%20to%20its%20lipid%20solubility.&text=So%2C%20in%20this%20case%20pH,the%20drug%20is%20ionized%20halfly.
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