Will you be able to screen the synthesized compounds for Tau Protein Inhibition Invivo and perform Binding studies?

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Is there any database available for Electrodermal activity, Galvanic skin conductance ?

Is there any publicly accessible database that recorded electrodermal activity at different conditions?

04 August 2021 1,428 1 View

Improvement of Mechanical properties by changing the general composition of a stainless steel and by adding some other elements into it?

Changing of standard stainless composition (Iron alloy with minimum % of chromium is 10.5%, 1.2% of carbon and ferrous, carbon chromium) which can improve, a. Anticorrosion properties (chemical...

31 March 2021 8,331 4 View

How to obtain linearly varying component of pressure gradient in periodic flows in Fluent?

The pressure drop between the modules in periodic flows (such as in a pipe) is periodic. This pressure gradient can be decomposed into a periodic and linearly varying component. The linearly...

05 June 2020 4,413 0 View

How to convert Sound Pressure Levels in excel to corresponding audio file in MATLAB?

I have experimentally recorded the Sound Pressure Levels of a horn. The SPLs have been obtained through simulation from LMS. But the output of LMS is in the form of spectrum in excel. I want to...

25 February 2017 6,920 5 View

Does de-ionized water change color of a substrate coated with some chemical?

Out of curiosity, I would like to know whether any chemical coating on a substrate change its color when de-ionized water touches it. Precisely, if I pass some water through a microchannel in...

22 October 2016 5,079 3 View

Is Bi2Te3 a type of Topological Insulator an antiferromagnetic material or not?

Since, the entanglement occurs mainly in anti-ferromagnetic materials as their spins are aligned in random way. Kindly, let me know how to find out in general a material has the same nature or...

17 October 2016 7,661 2 View

Why is there no velocity in output for harmonic analysis in ABAQUS?

I modeled a simple rectangular plate in ABAQUS to perform a harmonic analysis with 1N force at the centre fixed on the edges and used 'Steady state dynamics, Direct'. But I get '0' velocity...

09 August 2016 5,484 5 View

Why does my protein precipitate when i add TEV protease to cleave the GST tag?

Upon incubation of my protein with O/N with TEV protease (in 50mM Tris, 0.5mM EDTA), in the morning i saw a white thready precipitated formed. After running the SDS gels, following coomassie...

28 June 2016 5,119 6 View

Do ANSYS APDL and workbench produce same modal results for a particular problem? If not what is the error range?

I am trying to perform a Modal analysis on a thin circular plate. But the results on both the platforms do not match. Am i doing something wrong?

23 May 2016 8,174 3 View

Is it possible to get a vertical wall in wet etching of silicon?

I would like to know whether it is possible to get vertical side walls in etching of either or silicon wafers using TMAH/KOH based wet etching processes. In general, if I...

12 April 2016 8,914 8 View

Why does my protein refolded to beta sheet during thermal denaturation analysis?

Hi! So i attempted to understand a novel protein behavior towards heat application by analyzing its secondary structure change. I subjected the protein to a thermal denaturation analysis using...

06 August 2024 1,989 3 View

Weak DAPI staining after immunohistochemistry - how to improve?

After immunohistochemistry of previously fixed in PFA and EtOH and then frozen 20 μm sections of zebrafish brain, DAPI staining is very weak (right) compared to the same sections stained without...

05 August 2024 9,637 2 View

The Curse of Evolution and Complexity?

Brain and body mass together are positively correlated with lifespan (Hofman 1993). The duration of neural development is one of the best predictors of brain size, and conception is the best...

05 August 2024 6,247 3 View

Transfection in HEK293T cells?

Dear All, I am trying to transfect a pCDNA3.1 vector containing my gene of interest. The purpose is to figure out the localization of the protein of interest. I have fused the protein with GFP on...

31 July 2024 9,892 4 View

How to retain the a GFP tagged gene expression in stable cell line?

Hello , I established a stable cell line expressing GFP tagged to a centrosomal gene having G418 drug selection marker. I validated the stable line by IFA and Western blotting, results are fine....

29 July 2024 5,007 0 View

I am working on my Master's thesis on the biogeography of the genus Ruagea and I would like to ask, could someone help me to check whether my result?

I created a file with my outgroup and ingroup species using Beauti, ran it in BEAST, viewed it in Tracer, and then used TreeAnnotator to create a file that I imported into RASP. Could someone...

28 July 2024 2,979 1 View

What is the relationship between protein structure and N or C terminal tagging choosing?

I want to do 2,3-butanediol dehydrogenase(BDH) enzyme purification to confirm its activity for 2,3-butanediol. Before that, I need to confirm which N or C terminal tagging is better for enzyme...

28 July 2024 366 3 View

What is the best method to detect the chemical composition of pollen ?

I have multiple small samples of grass pollen with anthers. I want to find a method to identify concentrations of proteins, lipids, and other various elements for these samples. any suggestions?

28 July 2024 5,331 1 View

Could you try using PeptiCloud and see if it's a useful tool for biology research?

PeptiCloud (www.pepticloud.com) is a bioinformatic platform that allows researchers to organize and share their data for their projects as well as collaborate with others in one place. Through...

28 July 2024 4,762 2 View

Why cannot i find my protein on cell surface after antibiotic selection of expressing plasmid?

I cannot confirm cell surface protein expression by flow cytometry even after transfection and antibiotic selection of cells. Does it take long for proteins to express on the cell surface? the...

28 July 2024 3,178 3 View

Thomas J Raub

Have you considered submitting to Eli Lilly's Open Innovation program (https://openinnovation.lilly.com/dd/)?

Anvesh Jallapally

Thanks Thomas.. but we usually we go for osdd programme by our institute CSIR.

Fernanda Yévenes

You could contact Ashley Bush and Paul Adlard (my supervisors) at The Florey Institute of Neuroscience and Mental Health to see if they can help you out with a collaboration. Cheers

Thanks Fernanda..!!! For sure, I would contact them

Regards

Anvesh