Will it always be the activation of transcription when ERK is phosphorylated in the MAPK signal pathway?

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Kristina Sharlo

it depends of what protein it is. ERk1/2-dependent pathway can both activate or repress transcription of certain gene, depends on what gene it is.

Anita Ma

Thank you for the reply. I searched in Pubmed, but all the papers i found about phosphorylated ERK1/2 was the activation of genes. Could you please give an example of repression? Thanks! Kristina Sharlo

For example, Article Control of cell death and mitochondrial fission by ERK1/2 MA...

https://pubmed.ncbi.nlm.nih.gov/14593115/

Thank you very much! Kristina Sharlo