Will ALL acute lymphoblastic leukemia T lymphocyte/B lymphocytes protect themselves from foreign substances (Microbes) in cancer patients? If Yes, how will they do this? Being immature cells, how can they protect themselves from infectious agents?
If the answer is no, then why don't we artificially infect the ALL cell within the bone marrow, where the bone marrow of the ALL patient is completely occupied by immature T lymphocyte/B lymphocytes and allows little room for the normal immune cell?
I am not sure I understand the question, however, I would say that in general, a leukemic cells spends the majority of their energy replicating and of course maturation is stalled. Patients in a blast crisis are susceptible to infection due to the lack of mature, functioning immune system cells. I think this is the answer to the second part of your question - if you infect the patient with microbes, you are putting the patient at great risk of developing a life threatening infection.
The answer is a clear no, If that would be the case, an T-ALL patients with high levels of blasts might never have a bacterial infection. Even if they are morphologically intact, functionally they lack their immune functions..
I agree with Prof Hamdi and I think that depend on the percentage and type of blast cells and the function of macrophage cells (Monocytes and neutrophils) . According to some studies , there is no impairment of phagocytic ability , but 36% of patients in relapse and 25% in remission had varying degrees of diminished intracellular killing capacity of bacteria.
Once again Huge Hi ,to all of you ..
From all Your answer . it is obvious that leukemic patient are much prone to infection .Leukemic cell lack patrol am i right ,they dont have ability to defend against the microbes or invading pathogen.
Why dont we selectively infect Leukemic cell with microbes. ?Will it b a feasible way to kill leukemic cancer ..
Albeit some cancer cells do perform Phagocytosis (Entosis) . Cell etaing cell to avert starvation .. Why dont we increase starvation in tissue specific .by which more cancer cell will compitite to engulf the nearby cancer cell ,by whch tumor burden might decrease .more over the survival of the fittest alone will persist in tumor.
would you please leave comment on this ..
Thanking you all
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