Possible explanation for good in vitro antioxidant activity of plant extracts but poor in vivo protective activity?

Is there any possible explanation of a plant extract having a good in vitro antioxidant activity but poor in vivo protective activity or probably toxic in vivo? Any relevant article is highly...

03 April 2019 3,715 3 View

Histology results versus biochemical results?

Is it possible for a drug to have little or no toxic effect on the histology of a particular organ, say the liver but a significant negative effect on same organ from the results of Biochemical...

03 April 2019 1,698 5 View

What is really the standard duration of cold extraction?

Most cold extraction of plant samples by maceration are reportedly done for 72 hours (3days). Is there any SIGNIFICANT consequence of leaving it a beat longer say 5days or 6days? Would the active...

07 August 2018 2,935 3 View

Can Rat-specific assay kits be used with spectrophotometers?

I have discovered that rat-specific research assay kits are ELISA kits designed to be used with microplate readers. Are there no such kits that can be used with spectrophotometers?

06 July 2018 7,626 0 View

How long can a pulverized dried leaf sample be stored before use? Up to one year?

Can I store pulverized and completely dry leaf samples up to one year before extraction?

03 April 2018 6,409 4 View

Please what is the best method of drying n-hexane extract of plant samples to yield a dry solid that can be dissolved in water?

I want to know how i can concentrate n-hexane plant extract and subsequently dry it so the shelf life can be extended.

31 December 2016 6,233 7 View

How can I measure MMP-1 protein activity or protein level from liver tissue?

Instead of checking only the mRNA level, I want to check the active protein level of MMP-1 in Liver tissue from mice. How can I do that?

03 March 2021 1,763 2 View

Looking for Materials with high thermal expansion coefficient and high temperature resistance?

03 March 2021 8,272 1 View

Does any one know how i can prepare liver tissue with transmission electron microscope with good fixation?

i have problem in preparation of liver tissue with bad cell organelles and how i can adjust osmolarity

03 March 2021 8,890 1 View

What are the most reliable approaches to extract key continuous frames from a video, with complete automation?

I have an input video, of skin (from a microscope that means it is magnified such that blood capillaries are visible). The idea is to extract 15 sec of continuous frames from a video of 1 min,...

02 March 2021 2,735 2 View

How does the gut microbiome affect the fibrotic process within the liver?

and Can the gut microbe be used for the treatment or diagnosis of liver fibrosis?

02 March 2021 557 2 View

Research on Supply Chain Management in Indian context?

Hi, I am planning to apply for the PhD degree in the Supply Chain Mgt. with specific area of "Cold Storage warehouses" during Pandemics and wars. Where lock downs and shut downs are frequent....

02 March 2021 285 2 View

How can extract ciprofloxacin hydrochloride disolve in water er to organic solvent such as dichloromethan or any other solvent?

I need a procedure to extract the ciprofloxacin hydrochloride from aqueous solution by using dichloromethane in detail,. I thank you very much.

01 March 2021 4,306 1 View

How can you bring two structures together to create an adhesive bond in LAMMPS?

I have created an Ice 1h crystalline structure and an Aluminium substrate structure and equilibrated both at 250K. Now I need to bring them together in a way that an adhesive bond is created....

01 March 2021 3,325 2 View

Which bacteria are suitable for quorum sensing screening?

I want to find a quorum sensing inhibitor from plant extracts. Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, and Streptococcus pneumoniae. I looked for these strains...

01 March 2021 7,675 3 View

IHC on mouse liver hepatocytes?

Can anyone help me choose primary antibodies for mouse liver hepatocytes and also in conjunction Cd8 cells. Also Cd3 cells. I want to look at hepatocytes and adjacent immune cells in mice with...

01 March 2021 6,953 1 View