Im using 40nm of gold nanoparticle incubate with 50% of human serum. By using the malvern zetasiver, I got -46.5mV for bare nanoparticle. After incubated it with human plasma to form protein corona, I got -9.94 mV. The negativity has decrease. Why the negative value decrease?
And I read that +/- 10mV to +/- 30 mV of sample is incipient stability. Is my sample considered as instable after incubated it with protein source?
Omar Gonzalez-Ortega
Proteins are getting adsorbed thus modifying the zeta potential. Your zeta potential value will increase due to charges (or absence of them) in these protein molecules. Your particles could be unstable due to the reported measurement if this was performed in a proper way and the equipment is properly working.
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