Mucin is secreted from goblet cells and is protective in nature. But it is found that mainly acidic mucins i.e. sulfomucin and sialomucin has been present in different proportion in normal colon and inflammatory or cancerous colon.
Variation in sialo- and sulfomucin content may influence microbial colonization. For example, sulfate derived from sulfomucin degradation may promote the colonization of sulfate-reducing bacteria (SRB), which through sulfate respiration generate the genotoxic gas hydrogen sulfide.
Article On the Relationship between Sialomucin and Sulfomucin Expres...
Thank you so much...
I wanted to know about reason behind this conversion rather than the mechanism.
Article Sulfate-reducing bacteria stimulate gut immune responses and...
The intestinal microbiota is critical for mammalian immune system development and homeostasis. Sulfate-reducing bacteria (SRB) are part of the normal gut microbiota, but their increased levels may contribute to colitis development, likely in association with hydrogen sulfide (H2S) production.
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