Why it is a common practice to use S. cerevisiae alpha-glucosidase instead of the human enzyme, for in-vitro and in-silico/docking enzyme inhibition studies? Even the sequence of the yeast and human protein is not exactly the same.
Chinaza Godswill Awuchi
Check https://www.jyi.org/2020-october/2020/10/1/structural-analysis-of-a-new-saccharomyces-cerevisiae-glucosidase-homology-model-and-identification-of-potential-inhibitor-enzyme-docking-sites
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Chinaza Godswill Awuchi
Also check https://www.tandfonline.com/doi/full/10.1080/14756366.2017.1368503
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Chinaza Godswill Awuchi
And https://www.sciencedirect.com/science/article/pii/S2405844020312366
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