Dear Vinod Gurjar ,
Sulphonamides, other than Sulfacetamide are or have been used in the treatment of eye infections, namely Sulfadiazine, Sulfadicramide, Sulfafurazole, Sulfamethylthiazole, Sulfathiazole. I'm not aware if it has been an off-label use or an approved therapeutic indication. However, most of the sulfa-based eye preparations contain Sulfacetamide and I guess it will be due either to absorption or side-effects/toxicity related issues (but haven't found any supporting reference).
I hope it helps.
Kind regards, Luis
Please see below a summary of info from Martindale:
Sulfacetamide is a sulfonamide antibacterial that is used with sulfabenzamide and sulfathiazole in preparations for vaginal use, and is applied, as the sodium salt, in infections or injuries of the eyes, although it is rarely of much value. Eye drops containing sulfacetamide sodium 10% to 30% and eye ointments containing 10% have been used.
Sulfadiazine silver has also been used in other skin conditions, such as leg ulcers (p.1585), where infection may prevent healing and for the prophylaxis of infection in skin grafting. It has also been applied to the eyes in the treatment of superficial Aspergillus infections.
Sulfadicramide is a sulfonamide with properties similar to those of sulfamethoxazole (p.340). It is applied as a 15% ointment for superficial infections of the eye.
Eye preparations of sulfafurazole diolamine should not be applied with preparations of silver salts. Sulfafurazole diolamine has been used, as an ophthalmic ointment or solution containing the equivalent of 4% of sulfafurazole, in the topical treatment of susceptible eye infections.
Sulfamethylthiazole is a sulfonamide with properties similar to those of sulfamethoxazole. It is applied topically with tetracycline in the treatment of eye infections.
Sulfathiazole is a short-acting sulfonamide with properties similar to those of sulfamethoxazole. It is now rarely used systemically due to its toxicity. Sulfathiazole sodium has been applied topically with other drugs in the treatment of eye infections
as per my knowledge the Pka value of sulphacetamide is around 5 and other sulfonamides have around 7. so that solubility of sulphacetamide is more in aqueous solvent. that''s why it is suitable for eye drop preparation
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Pharmaceuticals
- Drugs