1- Saliva buffer acts as an important factor to control the pH of the mouth environment.
2- We found that the Salivary pH of Type 1 diabetes patients was significantly reduced 13.5% compared to controls, caused by lower SFRs which refers to a reduction of the buffer salivary capacity, microbial activity, and increasing of caries risk.
Aljerf L. and Alhaffar I. 2017. Salivary distinctiveness and modifications in males with Diabetes and Behçet's disease. Biochemistry Research International. 2017, 1–12. DOI: 10.1155/2017/9596202
Hello, Median salivary flow rate was 0.48 ml/min (range: 0.1-2 ml/min). Age younger than 44 years was associated with higher flow rates (OR 2.10). Compared with women, men presented a higher flow rate (OR 3.19) and buffer capacity (OR 2.81). Bicarbonate concentration correlated with salivary flow rate. The lower-end values of normal flow rate and bicarbonate concentration were 0.15 ml/min and 1.800 mmol/l, respectively.
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I don't know about saliva, but there is an important difference between pH and buffering capacity. pH is -log[H+], i.e. the concentration of hydrogen ions. Buffering capacity is the ability of the solution (saliva in this case) to resist a change in pH caused by the addition of acid or base. Buffering capacity is the result of the presence of protonatable substances (buffers) in the solution. The buffering capacity is maximaI if the equilibrium constant for dissociation of H+ from the buffer (pKa) of a buffer is close to the pH of the solution. If the pH is far from the pKa of the buffer, the buffering capacity will be low.
For example, the widely used buffer Tris has a pKa of 8.1 at 25oC. It has its highest buffering capacity at that pH. At pH 6, it has very little buffering capacity.
Another factor in buffering capacity is the concentration of the buffer. The buffering capacity of a solution containing a buffer increases with the concentration of the buffer.
If there is a lack of correlation between salivary pH and buffering capacity, it may be because the pH is not close to the pKa of the buffer, or because the concentration of the buffer is too low to support much buffering at the saliva pH.
Hello, Median salivary flow rate was 0.48 ml/min (range: 0.1-2 ml/min). Age younger than 44 years was associated with higher flow rates (OR 2.10). Compared with women, men presented a higher flow rate (OR 3.19) and buffer capacity (OR 2.81). Bicarbonate concentration correlated with salivary flow rate. The lower-end values of normal flow rate and bicarbonate concentration were 0.15 ml/min and 1.800 mmol/l, respectively.
For more info see attached info.
Good luck!
Hi
Of course there are difference between pH and buffering capacity, I agree with Karen A. Darbinyan answers.
regard
There are at least two (common) misconceptions here. The pH in biological fluids is determined by two factors that balance each other: The difference between negative and positive strong ions (in this case Na + K - Cl) and the concentration of weak acid anions (in this case bicarbonate). Only weak acids and their anions have some buffering capacity near the pKa of the acid. The sum Na+K-Cl is always positive and a solution where the difference is say 40 mmol/l is strongly alkaline (think about a solution of NaOH). This solution is then back titrated with carbonic acid (CO2) to get the desired pH. The resulting bicarbonate ion may have some buffering effect if the pH happens to be near the pKa of carbonic acid but in principle the role of CO2 is to adjust the pH.
Another problem in the article is using percentage when comparing a logarithmic quantity. They should talk in terms of hydrogen ion concentration.
https://www.mathsisfun.com/definitions/logarithmic-scale.html
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