1.What is the hindrance?
2.Are all the chemicals compounds in honey fully identified yet or are there still 'unidentified compounds?' that may contribute to antimicrobial activity.
It has been used since the ancient but the lack of answers and updated answers to this questions frustrates me.
I don't know the answer either, but I can speculate it is because of a lack of clinical trials using honey versus some other treatment. And there would be difficulty in sourcing the best kind of honey, i.e., it would be difficult to control the biological parameters of the bees, what kind of pollen they gather, etc., which is something regulatory bodies might ask about especially if there are differences between types of honey in their antimicrobial activity. I also suspect that honey does not work as well as other antibiotics on the market, although I do not know this for sure. It's also a little messy.
I do not exaggerate when I state that most of the honey, in the market, is adulterated and thus unreliable. Add to it, the giant pharmaceutical companies have much more emphasis upon employing synthetic compounds in formulations of medicines rather than natural products.
Yes, there are unidentified substances in honey and this product still needs more research. As you know, honey comes in variety of tastes & colors and these are indicatives of the existence of various compounds that require identification. In the past, a given natural product was said to have, say 10 ingredients, but upon the arrival of sophisticated equipment, the number has doubled or tripled.
When I see some scholars who do not do research or when some research topics are not targeted, I usually wait to see the full context of what is going on to put things in the proper perspective.
The natural and traditional remedy of honey is more effective in medical treatments than most of the commercial drugs but emphasis is not given to the biochemical characterization of honey. The health benefit of honey is articulated in the following paper and have a look. I love honey.
http://www.sciencedirect.com/science/article/pii/S0102695X16301843
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