Thymoquinone and Dithymoquinone are found in black seeds (Nigella sativa).
From their structures, dithymoquinone has 2 rings while thymoquinone has 1 ring. One would expect that dithymoquinone would be a better drug candidate than thymoquinone; hence there should be more work on it. But the reverse is the case, while there are numerous works on thymoquinone, works on dithymoquinone is almost none existent! Is there any particular reason for this please?
Dear Olayinka Sunday Okoh
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https://www.sciencedirect.com/topics/medicine-and-dentistry/thymoquinone
Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It is also found in select cultivated Monarda fistulosa plants grown in the U.S. which can be steam distilled to produce an essential oil.In laboratory experiments in cells and in animals, it has shown antiinflammatory and antioxidant effects, and it has been studied in models of cardiovascular diseases and diabetes, neurodegenerative diseases and stroke, and cancer. A 2016 study suggests thymoquinone may have opioid tolerance-reduction effects.
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