In a recent experimentation where we tested an agent's effect on the oxidative stress status on mice (inflammatory model of IBD), we found that livers and colons present a similar response plot.
In the aim to dig deeper, we tried to test our agent on mitochondrial swelling (in vitro). We were surprised to find that low doses induced a significant decrease in Liver mitochondrial activity compared to colons, which were not affected.
any speculation regarding this phenomena is deeply appreciated.
PS: The agent used has a metalloid characteristics.
What are the differences between liver and colon mitochondria may be the first question to answer? Some inflammatory products influence some pathways but not others due to their multiple, or single targetted effects.
Logic, not current expertise.