80% of papers report the use of carbon tetrachloride though it is a hazardous chemical while there are other reagents which can induce hepatotoxicity. Why?
Please read:
The following abstract
http://ac.els-cdn.com/S0378427410008416/1-s2.0-S0378427410008416-main.pdf?_tid=285b5f76-c87f-11e4-8c99-00000aab0f01&acdnat=1426141099_9201539010f74ed794cfceabf336a5ff
AND the manuscript
http://ac.els-cdn.com/S0022480406004926/1-s2.0-S0022480406004926-main.pdf?_tid=959b31f2-c87e-11e4-99d6-00000aab0f27&acdnat=1426140853_d5831c475538bbb752c943fbeabe3798
Paracetamol is a well known analgesic used usually in doses of 400 mg/ tablet and in a daily dose not to exceed 2 gm/day for safety purposes. Toxicity incidence by paracetamol might start by using doses higher than 4 gm/day, however, we can control this incidence upon using some food stuffs (having aminoacids contain mercapto group)to interact with the iminoquinone (the toxic intermediate) to form a product which will be excreted safely without affecting liver.
About ethanol, it is tolerable within the concentrations that not affect the mood of a man and will be easily oxidized to acetic acid as well as being execretd unchanged from the lung. It is found as a solvent mixed with water in some pharmaceutical products known as elixirs, for dissolution purposes.
Halogenated solvent (like CCl4, CHCl3, CH2Cl2 and others are not easily metabolized and recyclized by liver and, upon metabolism by liver enzyme producing free radicals that attack liver cells
CCL4 affects so much more than liver and kidneys, it causes damage to ALL tissues. Try finding publications that are explaining its effects. The most known effects are on liver and kidneys (due to their functions in metabolism and excretion) but the reactive CCL3 radical formed causes massive damage to ALL tissues (in highers or lesser extent).
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