The Herpes viruses infect neurons and hide in the gangelia, so the immune system couldn't clear it. Up to date there is no way to permanent removal of HSV and all antivirals only affect on local or systemic. Theoretically it can be removed by specifically treatment of latency site ( neuron or etc ), althogh it may be so difficult or impossible proccess.

Good luck

Very difficult to remove. The viral particles exploit receptor-mediated entry into particular site of neuron system. Herpes virus enters into root ganglion system, which is beyond reach of effective drug treatment. Only, during retrograde flow, viruses come in contact with drug which is not very frequent during prolong infection. Successful vaccination and Immuno-therapy is the best choice as hosts' own immune system will target virus bodies all the time.

In addition to what is said above some links from newstickers.

http://www.eurekalert.org/pub_releases/2013-10/lu-kmb100213.php

http://www.cmu.edu/mcs/news/pressreleases/2013/0724-virus-internal-pressure.html

http://www.eurekalert.org/pub_releases/2013-06/uoc--hve060613.php

http://www.newscientist.com/article/dn23073-straitjacket-drug-halts-herpes-viruss-escape-stunt.html

http://www.eurekalert.org/pub_releases/2012-10/foas-haw103112.php

http://medicalxpress.com/news/2011-09-discovery-ways-herpes.html

http://phys.org/news/2011-01-visualize-herpes-virus-tactical-maneuver.html

http://www.eurekalert.org/pub_releases/2010-04/lm-tso042210.php

http://feeds.feedburner.com/~r/reuters/scienceNews/~3/381730653/idUSN0244571620080902

http://www.eurekalert.org/pub_releases/2007-12/uop-prs121307.php

http://www.eurekalert.org/pub_releases/2007-06/wuso-hvh061307.php

http://www.eurekalert.org/pub_releases/2006-09/uoia-ssh092006.php

http://www.eurekalert.org/pub_releases/2007-12/uop-prs121307.php

http://www.newswise.com/articles/view/521258/

http://www.foxnews.com/story/2005/07/26/gene-may-help-herpes-virus-enter-cells/

http://www.eurekalert.org/pub_releases/2005-07/uomh-ho072105.php

http://www.eurekalert.org/pub_releases/2002-08/wuso-rdh082002.php

Regards,

Joachim

Because it integrates its genome in trigeminal nerves. How to remove? Forget about it. How to prevent expression? With lysine. How to further prevent expression?

iRNA? Any other questions??

The HSV is quiescent in the nerve, producing few viral proteins. Because of this, there is few virus´ peptides being presented to MHC class I. The neurons have very low molecules of MHC I. Therefore, the CD8+ T cells cannot recognize and attack infected neurons effectively. Could be an explanation...but there are many theories.

As far as I know, its not proved that Human herpesviruses integrates its genome, but there are evidences, as you can read below:

"Integration of viral genomes into the host's chromosomes is mandatory for the successful completion of the life cycles of several viruses, including retroviruses and adeno-associated viruses (AAV). In contrast, herpesviruses maintain their genomes as extrachromosomal circular episomes in the nuclei of infected cells without the need for integration. However, there have been several reports of chromosomally integrated herpesvirus (CIHHV) DNA over the years, suggesting that herpesviruses can indeed integrate into the host's chromosomes under certain conditions." (Herpesviruses and Chromosomal Integration, Guillaume Morissette1 and Louis Flamand, 2010).

Terry, I agree with iRNA ...

Regards and sorry about my English.

No problem, you expressed yourself very well. Delivery of iRNA to cells infected with herpesvirus (cells infected with other members of the Herpesviridae) is problematic. RNA is notoriously susceptible to degradation. The only answer I can think of is liposomal delivery with the liposomal outer membrane armed with antibodies against herpes viral proteins. These will have to be administered locally, close to the sites of infection. Otherwise, they will likely be cleared by normal phagocytosis prior to reaching their targets.

Point is, site of infection is difficult to locate; for benign like gamma herpes infection, it takes a month to show symptoms depending on immune status of hosts. The other herpes group of viruses including genital herpes , after entry, takes around 2-4 weeks to show papules, chancre and warts. Drugs cannot reach smoothly to nerve ganglia for treatment and there is, practically no drugs to completely treat herpes.

Your concept is partially in right direction- selective (viral antigen specific) raise in immune responses is a solution; which is immunotherapy. This may be synthetic T cell (TCR) vaccine or epitope vaccine . Innate immune responders of R848 groups are good introduction in herpes therapy related research. The possibility of iRNA or microRNA can't be ruled out at this point as, shield can be used to make these RNAs undegradable. But, what essential is to link this RNAs with target specific mobility (insertion) sequences, which will help it to find infected ganglionic neurons. This is interesting, feasible but time consuming and costly.

There are several surface glyco-proteins produced by herpes virus. Among these gC is important which binds complement C3 protein and thus depletes it from the host's serum and inhibits complement-mediated reactions. The virus gE and gI proteins can also bind IgG via the Fc portion of the immunoglobulin. This coats the virus with immunoglobulin and hides it from the immune system. Herpes virus infects epithelial mucosal cells or lymphocytes. Virus then travels up peripheral nerves to a nucleated neurone where it may stay for years followed by reactivation. During reactivation due to mainly stress -related or other immune-supression factors, these virus again travel down through axon to the opposite direction and cause symptoms.

Though there is no proved effective measure to control recurrence, we have a study with levamisole, an immunomodulator, that can be used to prevent frequent recurrence especially herpes keratitis which can lead to blindness.In a follow up of a case of herpes zoster with monthly recurrence, levamisole was given and more than 7 years passed, we didn't find any recurrence. Levamisole has a good effect preventing many other recurrent infections in immunodeficient patient.

https://www.researchgate.net/publication/230770273_LEVAMISOLE_IN_THE_PREVENTION_OF_RECURRENT_INFECTIONS_IN_IMMUNOSUBNORMAL_CHILDREN

Article LEVAMISOLE IN THE PREVENTION OF RECURRENT INFECTIONS IN IMMU...

Herpes virus enters into root ganglion system, which is beyond reach of effective drug treatment