2-mercaptobenzothiazole loaded silica has been stirred in 3.5 wt. % NaCl in H2O solution. The release of MBT was evaluated by UV-Vis in different pHs (3 - 11). However, the highest release of MBT occurs in neutral pH (7); why?
What is the pKa (or pKa's) of your molecule? What is the water solubility of your molecule?
Thanks for your attention
pKa is about 7 at 20°c
Water solubility: 117mg/L ,Although in some cases it has been reported in the range of 100 to 1000 mg/L
You can find information to help explain your results here:
Article A computational UV–Vis spectroscopic study of the chemical s...
How did you keep silica from dissolving at high pH?
Thanks for your help
Due to what this article said, pKa is almost equal to Neutral pH. Besides, MBT- was released at pH>7 and MBTH+ was released at pH
According to the manuscript:
"On the other hand, functionalized mesoporous silicas were not stable in alkali solutions due to the breaking of the Si–O–Si bonds by hydroxide ions attack", hence my question.
It seems the degradability is dependent of the functionalization, however, the base structure of silica materials is chemically stable
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