We are analysing a compound and found one impurity. The limit we explained for this is 0.10% max. When we analysed this product on Dionex RSLC having PDA detector we got this impurity with in the specification limit ( 0.075%). When we analysed same solution in the same condition with Agilent 1260 having PDA we got this impurity out of specification (0.117%).

Can anybody help me to understand why this phenomenon is happening?

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