Why do some chemicals show GSH depletion, but no statistically significant decrease in (rat or mouse) cell survival in vitro?

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Pratima Tripathi

Dear Bin,

In some cultured cells like myocytes, up-regulation of Bcl-2 inspite of ROS generation that depletes, GSH, cells can survive by mimicking physiological activation, i.e. Bcl-2 up-regulation is the main factor for cell survival.

Also check the attachment for clear discription.

All the best.