After a special treatment of mice with chronic liver disease, I see a significant increase of monocyte-derived macrophages in the liver along with increased fibrosis and compensatory proliferation.
I stained liver section for Cl.Casp3 (Apoptosis) and observe that these monocytes (besides hepatocytes) are also apoptotic.
Can anyone give me hints why these monocytes undergo apoptosis inside the liver? Don't they support the inflammatory milieu?
Thanks!!