Why develop KO mouse model?

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Yuan-Yeu Yau

So you will know what the function of the gene (which was KOed) is in the mouse. You probable can see a 'phenotype' on the mouse.

Wei Li

But if you have alread known the function of the gene you study, what areas will you have to employ KO mouse?

Have you seen this site about 'Knockout mouse' (from the NIH website): https://www.genome.gov/12514551/knockout-mice-fact-sheet/#al-2

It explains:

What is a knockout mouse?

What are knockout mice used for?

What are the drawbacks of knockout mice?

How are knockout mice made?

Thanks so much ~ I even forgot there is a such wounderful website providing relevent information.

Thanks again