Why develop KO mouse model?

More Wei Li's questions See All

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why

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Yuan-Yeu Yau

So you will know what the function of the gene (which was KOed) is in the mouse. You probable can see a 'phenotype' on the mouse.

Have you seen this site about 'Knockout mouse' (from the NIH website): https://www.genome.gov/12514551/knockout-mice-fact-sheet/#al-2

It explains:

What is a knockout mouse?

What are knockout mice used for?

What are the drawbacks of knockout mice?

How are knockout mice made?