Some answers come in a recent webinar where my close colleagues from VRCM* cover this question based on their own experience and that from other groups in the field. This recorded talk is available on-demand at: www.stagowebinars.com
*) F. Dignat-George & R. Lacroix from Vascular Research Center of Marseille (F), see corresponding ResearchGate pages
https://www.stagowebinars.com