Hi Sehej

Pseudounipolar pattern of sensory neurons acts as low-pass filtering, potentially regulating sensory information reaching the spinal cord. Thus, by impedance mismatch between membrane point in the vicinity of T-junction, this has been recognized as a site where spike propagation may fail.

As for action potential propagation through the axon, this is a more broad question. Actually, in a really simplistic summary, sensory neurons have "transductors" (specialized proteins that converts physical energy - thermal, mechanic, chemical - into electrical signal) in their peripheral end; these transductors creates a "generator potential", according to specifical thresholds. If, and only if, these generator potentials reach some specific area in the membrane with a larger density in voltage gated channels (as Na channels) within these second step threshold, an action potential (spike) is generated and conveyed until the "T-junction" filter described above.

Some references for better comprehension

1 -Al-Basha, Dhekra, and Steven A. Prescott. "Intermittent Failure of Spike Propagation in Primary Afferent Neurons during Tactile Stimulation." Journal of Neuroscience 39.50 (2019): 9927-9939.

2 - Sundt, Danielle, Nikita Gamper, and David B. Jaffe. "Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study." Journal of neurophysiology 114.6 (2015): 3140-3153.

Regards,

Tiago Avelar

Hi Sehej

Pseudounipolar pattern of sensory neurons acts as low-pass filtering, potentially regulating sensory information reaching the spinal cord. Thus, by impedance mismatch between membrane point in the vicinity of T-junction, this has been recognized as a site where spike propagation may fail.

As for action potential propagation through the axon, this is a more broad question. Actually, in a really simplistic summary, sensory neurons have "transductors" (specialized proteins that converts physical energy - thermal, mechanic, chemical - into electrical signal) in their peripheral end; these transductors creates a "generator potential", according to specifical thresholds. If, and only if, these generator potentials reach some specific area in the membrane with a larger density in voltage gated channels (as Na channels) within these second step threshold, an action potential (spike) is generated and conveyed until the "T-junction" filter described above.

Some references for better comprehension

1 -Al-Basha, Dhekra, and Steven A. Prescott. "Intermittent Failure of Spike Propagation in Primary Afferent Neurons during Tactile Stimulation." Journal of Neuroscience 39.50 (2019): 9927-9939.

2 - Sundt, Danielle, Nikita Gamper, and David B. Jaffe. "Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study." Journal of neurophysiology 114.6 (2015): 3140-3153.

Regards,

Tiago Avelar

• Pseudounipolar neurons are sensory neurons that have no dendrites, the branched axon serving both functions. The peripheral branch extends from the cell body to organs in the periphery including skin, joints, and muscles, and the central branch extends from the cell body to the spinal cord.
• Sensory neurons are nerve cells within the nervous system responsible for converting external stimuli from the organism's environment into internal electrical impulses. For example, some sensory neurons respond to tactile stimuli and can activate motor neurons in order to achieve muscle contraction.
• Sensory neurons receive impulses and carry them from the sense organs to the spinal cord or brain. Interneurons connect sensory and motor neurons and interpret the impulse. Motor neurons carry impulses from the brain and spinal cord to muscles or glands.

Hi Sehej Bindra

A pseudounipolar neuron, as the name suggests, is a neuron which has only one extension from its cell body. It contains an axon that splits into two branches; one travels to the peripheral nervous system and the other to the central nervous system. The axon and the dendrite are formed from a single process arising from the cell body of the neuron. But instead of being called unipolar, they are called pseudounipolar, because, embryologically they develop as bipolar in shape. Like the pseudounipolar neurons that make up the mesencephalic nucleus for instance, which gets migrated into the brain stem during embryological development.

Most of them function in carrying information about touch, vibration, proprioception, pain, temperature and even information about taste from taste buds.

For exact information on how potential generation and passage happens in pseudounipolar neuron, and to the details regarding Summation, you can refer to this paper:

Article Morphological and functional diversity of first-order somato...

Hope it helps.