It should be investigated whether the CD8 over activation may be due to the presence of many other intrinsic and extrinsic antigen which arise as a result of chronic HIV immunosuppression? I have in mind cellular antigens and opportunistic infections or comensals which accumulate over time due to immune function backlog.A study should try to identify the specificity of the CD8s in relation to known co-infections such as herpes and hepatitis as well as cancer.

Article CD8(+) T Cells Are Activated in an Antigen-Independent Manne...