Dear Paul

please follow:

http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_03j.pdf

US FDA (2007) Summary of color additives listed for use in the United States in

food, drugs, cosmetics, and medical devices, color additives approved for use

in cosmetics Part 73.

Office of Cosmetics and Colors (N.M.H) and Office of Regulatory Science (Nutrition, US, Hepp, NM, Mindak,

WR, Cheng J). Center for Food Safety and Applied. Determination of total lead in lipstick: Development and

validation of a microwave-assisted digestion, inductively coupled plasma-mass spectrometric method. Food and Drug

Administration, Collage Park, MD 20740. 2009.

Bonjour Paul, félicitations pour tes résultats. pour évaluer l’intolérance d'une matière première cosmétique il existe des lignes directrices OCDE dédiées à ce type de tests. bien amicalement. Khalil.

Before any biotestings you may need to check the trace elements and heavy metal analysis (both in ppm scale safe limits) in your extract for it to be safe for bioapplications!

Dear Paul,

I agree with Riaz. Please be sure to check trace elements e.g. heavy metals, pesticides and solvent residues etc. and plant-individual constituents that might be restricted by REG. (EC) No 1223/2009 on cosmetic products and its amendments.

SCCS published a newer version of the notes of guidance Parisa stated above:

http://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_190.pdf

Please be sure to start no animal testing!