The drug is hydrophobic . The solubility of drug is less than 0.5 mg/ml in water, methanol and ethanol. But drug has very good solubility in DMSO. Is it good to use DMSO as the only solvent to load the drug in nanoparticles? How to remove DMSO completely from nanoparticles? The combination of 10% DMSO and 90 % water is correct or wrong?
It should work( DMSO and water). You can wash with water to remove remaining DMSO as both are miscible.
Dmso can be used completely. Dmso with combination of water (50:50) is best to use.
You shouldn't use a too good solvent for the drug; then the drug will rather remain in the solvent phase than adsorb to the silica surface. Actually wrote a paper on this almost ten years ago ;-) http://www.sciencedirect.com/science/article/pii/S0168365908001211
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