I have seen several validation for the SNP entries in ensembl genome browser and other tools like PolyPhen2, Panther, SIFT, PredictSNP etc., are available. Which prediction will be much helpful to take them for further studies? Kindly share your expertise.
I would suggest you to use several in silico tools and take the collective score to perioritize the SNP you are interested to study. These Studies will be helpful to your objectives
https://www.ncbi.nlm.nih.gov/m/pubmed/29047041/?i=3&from=hatem%20zayed%20prioritize
https://www.ncbi.nlm.nih.gov/m/pubmed/29893426/?i=2&from=hatem%20zayed%20prioritize
Good luck
Hi,
If you need to predict the effect of an SNP in clinical setting, you can follow the ACMG (American College of Medical Genetics and Genomics) Standards and guidelines https://www.acmg.net/docs/Standards_Guidelines_for_the_Interpretation_of_Sequence_Variants.pdf , in which you may find the classification criteria for your variants. You can look onto tools based on it's category (like missense, splice-site etc) and refer to population, disease specific and sequence databases.
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